Ontology highlight
ABSTRACT:
SUBMITTER: Chasse SA
PROVIDER: S-EPMC1405904 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Chasse Scott A SA Flanary Paul P Parnell Stephen C SC Hao Nan N Cha Jiyoung Y JY Siderovski David P DP Dohlman Henrik G HG
Eukaryotic cell 20060201 2
A common property of G protein-coupled receptors is that they become less responsive with prolonged stimulation. Regulators of G protein signaling (RGS proteins) are well known to accelerate G protein GTPase activity and do so by stabilizing the transition state conformation of the G protein alpha subunit. In the yeast Saccharomyces cerevisiae there are four RGS-homologous proteins (Sst2, Rgs2, Rax1, and Mdm1) and two Galpha proteins (Gpa1 and Gpa2). We show that Sst2 is the only RGS protein tha ...[more]