Ontology highlight
ABSTRACT:
SUBMITTER: Chinsangaram J
PROVIDER: S-EPMC140819 | biostudies-literature | 2003 Jan
REPOSITORIES: biostudies-literature
Journal of virology 20030101 2
We have previously shown that replication of foot-and-mouth disease virus (FMDV) is highly sensitive to alpha/beta interferon (IFN-alpha/beta). In the present study, we constructed recombinant, replication-defective human adenovirus type 5 vectors containing either porcine IFN-alpha or IFN-beta (Ad5-pIFNalpha or Ad5-pIFNbeta). We demonstrated that cells infected with these viruses express high levels of biologically active IFN. Swine inoculated with 10(9) PFU of a control Ad5 virus lacking the I ...[more]