Ontology highlight
ABSTRACT:
SUBMITTER: Jimenez R
PROVIDER: S-EPMC140891 | biostudies-literature | 2003 Jan
REPOSITORIES: biostudies-literature
Jimenez Ralph R Salazar Georgina G Baldridge Kim K KK Romesberg Floyd E FE
Proceedings of the National Academy of Sciences of the United States of America 20021223 1
Photon echo spectroscopy has been used to measure the response of three antibody-binding sites to perturbation from electronic excitation of a bound antigen, fluorescein. The three antibodies show motions that range in time scale from tens of femtoseconds to nanoseconds. Relative to the others, one antibody, 4-4-20, possesses a rigid binding site that likely results from a short and inflexible heavy chain complementarity-determining region 3 (HCDR3) loop and a critical Tyr that acts as a "molecu ...[more]