Ontology highlight
ABSTRACT:
SUBMITTER: Cenci S
PROVIDER: S-EPMC1409720 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
The EMBO journal 20060223 5
After few days of intense immunoglobulin (Ig) secretion, most plasma cells undergo apoptosis, thus ending the humoral immune response. We asked whether intrinsic factors link plasma cell lifespan to Ig secretion. Here we show that in the late phases of plasmacytic differentiation, when antibody production becomes maximal, proteasomal activity decreases. The excessive load for the reduced proteolytic capacity correlates with accumulation of polyubiquitinated proteins, stabilization of endogenous ...[more]