Ontology highlight
ABSTRACT:
SUBMITTER: Berger T
PROVIDER: S-EPMC1413671 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Berger Thorsten T Togawa Atsushi A Duncan Gordon S GS Elia Andrew J AJ You-Ten Annick A Wakeham Andrew A Fong Hannah E H HE Cheung Carol C CC Mak Tak W TW
Proceedings of the National Academy of Sciences of the United States of America 20060130 6
Diverse functions have been reported for lipocalin 2. To investigate these functions in vivo, we generated gene-targeted lipocalin 2-deficient mice (Lcn2-/- mice). In vitro studies have suggested that lipocalin 2 is important for cellular apoptosis induced by IL-3 withdrawal, and for the induction of kidney differentiation during embryogenesis. Analysis of Lcn2-/- mice showed normal cell death upon IL-3 withdrawal and normal kidney development. However, we found that Lcn2-/- mice exhibited an in ...[more]