Role of positive selection in the retention of duplicate genes in mammalian genomes.
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ABSTRACT:
SUBMITTER: Shiu SH
PROVIDER: S-EPMC1413713 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Publications
Role of positive selection in the retention of duplicate genes in mammalian genomes.
Shiu Shin-Han SH Byrnes Jake K JK Pan Runsun R Zhang Peng P Li Wen-Hsiung WH
Proceedings of the National Academy of Sciences of the United States of America 20060206 7
The question of how duplicate genes are retained in a population remains controversial. The duplication-degeneration-complementation model, which involves no positive selection, stipulates a higher retention rate of duplicate genes in a small population than in a large one. This model has been accepted by many evolutionists. However, we found considerably more retentions and fewer losses of duplicate genes in the mouse genome than in the human genome, although the population size of rodents is i ...[more]
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