Ontology highlight
ABSTRACT:
SUBMITTER: Banerjee A
PROVIDER: S-EPMC1413910 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Banerjee Ashish A Gugasyan Raffi R McMahon Martin M Gerondakis Steve S
Proceedings of the National Academy of Sciences of the United States of America 20060216 9
Engaging mammalian Toll-like receptors (TLRs) activate both the NF-kappaB and mitogen-activated protein kinase signaling pathways. Here we establish that mitogen-activated protein 3 kinase Tpl2, levels of which are markedly reduced in nfkb1(-/-) cells, is required for extracellular signal-regulated kinase (ERK) activation in bone marrow-derived macrophages and B cells stimulated with diverse TLR ligands. Despite rescuing TLR-dependent ERK activation in nfkb1(-/-) bone marrow-derived macrophages ...[more]