The discovery, positioning and verification of a set of transcription-associated motifs in vertebrates.
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ABSTRACT:
SUBMITTER: Ettwiller L
PROVIDER: S-EPMC1414082 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Publications
The discovery, positioning and verification of a set of transcription-associated motifs in vertebrates.
Ettwiller Laurence L Paten Benedict B Souren Marcel M Loosli Felix F Wittbrodt Jochen J Birney Ewan E
Genome biology 20051202 12
We have developed several new methods to investigate transcriptional motifs in vertebrates. We developed a specific alignment tool appropriate for regions involved in transcription control, and exhaustively enumerated all possible 12-mers for involvement in transcription by virtue of their mammalian conservation. We then used deeper comparative analysis across vertebrates to identify the active instances of these motifs. We have shown experimentally in Medaka fish that a subset of these predicti ...[more]
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