Ontology highlight
ABSTRACT:
SUBMITTER: Ridsdale A
PROVIDER: S-EPMC1415298 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Ridsdale Andrew A Denis Maxime M Gougeon Pierre-Yves PY Ngsee Johnny K JK Presley John F JF Zha Xiaohui X
Molecular biology of the cell 20060201 4
Although cholesterol is synthesized in the endoplasmic reticulum (ER), compared with other cellular membranes, ER membrane has low cholesterol (3-6%). Most of the molecular machinery that regulates cellular cholesterol homeostasis also resides in the ER. Little is known about how cholesterol itself affects the ER membrane. Here, we demonstrate that acute cholesterol depletion in ER membranes impairs ER-to-Golgi transport of secretory membrane proteins. Cholesterol depletion is achieved by a brie ...[more]