Ontology highlight
ABSTRACT:
SUBMITTER: Mellitzer G
PROVIDER: S-EPMC1422151 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Mellitzer Georg G Bonné Stefan S Luco Reini F RF Van De Casteele Mark M Lenne-Samuel Nathalie N Collombat Patrick P Mansouri Ahmed A Lee Jacqueline J Lan Michael M Pipeleers Daniel D Nielsen Finn C FC Ferrer Jorge J Gradwohl Gérard G Heimberg Harry H
The EMBO journal 20060302 6
Neurogenin 3 (Ngn3) is key for endocrine cell specification in the embryonic pancreas and induction of a neuroendocrine cell differentiation program by misexpression in adult pancreatic duct cells. We identify the gene encoding IA1, a zinc-finger transcription factor, as a direct target of Ngn3 and show that it forms a novel branch in the Ngn3-dependent endocrinogenic transcription factor network. During embryonic development of the pancreas, IA1 and Ngn3 exhibit nearly identical spatio-temporal ...[more]