Effects of streptomycin resistance mutations on posttranslational modification of ribosomal protein S12.
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ABSTRACT:
SUBMITTER: Carr JF
PROVIDER: S-EPMC1426572 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Publications
Effects of streptomycin resistance mutations on posttranslational modification of ribosomal protein S12.
Carr Jennifer F JF Hamburg Daisy-Malloy DM Gregory Steven T ST Limbach Patrick A PA Dahlberg Albert E AE
Journal of bacteriology 20060301 5
Ribosomal protein S12 contains a highly conserved aspartic acid residue that is posttranslationally beta-methylthiolated. Using mass spectrometry, we have determined the modification states of several S12 mutants of Thermus thermophilus and conclude that beta-methylthiolation is not a determinant of the streptomycin phenotype. ...[more]
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