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Gatifloxacin resistance and mutations in gyra after unsuccessful Helicobacter pylori eradication in Japan.

ABSTRACT: A high resistance rate (47.9%) to gatifloxacin (GAT; 8-methoxy fluoroquinolone) in Helicobacter pylori (H. pylori) strains from 48 Japanese patients is observed after unsuccessful H. pylori eradication. A significant association between MICs for GAT equal to or above 1 microg/ml and mutations of the gyrA gene of H. pylori was demonstrated.

SUBMITTER: Nishizawa T 

PROVIDER: S-EPMC1426923 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature

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Gatifloxacin resistance and mutations in gyra after unsuccessful Helicobacter pylori eradication in Japan.

Nishizawa Toshihiro T   Suzuki Hidekazu H   Kurabayashi Kumiko K   Masaoka Tatsuhiro T   Muraoka Hiroe H   Mori Mikiji M   Iwasaki Eisuke E   Kobayashi Intetsu I   Hibi Toshifumi T  

Antimicrobial agents and chemotherapy 20060401 4

A high resistance rate (47.9%) to gatifloxacin (GAT; 8-methoxy fluoroquinolone) in Helicobacter pylori (H. pylori) strains from 48 Japanese patients is observed after unsuccessful H. pylori eradication. A significant association between MICs for GAT equal to or above 1 microg/ml and mutations of the gyrA gene of H. pylori was demonstrated. ...[more]

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