Dataset Information

Optimal management of adults with pharyngitis--a multi-criteria decision analysis.

ABSTRACT:

Background

Current practice guidelines offer different management recommendations for adults presenting with a sore throat. The key issue is the extent to which the clinical likelihood of a Group A streptococcal infection should affect patient management decisions. To help resolve this issue, we conducted a multi-criteria decision analysis using the Analytic Hierarchy Process.

Methods

We defined optimal patient management using four criteria: 1) reduce symptom duration; 2) prevent infectious complications, local and systemic; 3) minimize antibiotic side effects, minor and anaphylaxis; and 4) achieve prudent use of antibiotics, avoiding both over-use and under-use. In our baseline analysis we assumed that all criteria and sub-criteria were equally important except minimizing anaphylactic side effects, which was judged very strongly more important than minimizing minor side effects. Management strategies included: a) No test, No treatment; b) Perform a rapid strep test and treat if positive; c) Perform a throat culture and treat if positive; d) Perform a rapid strep test and treat if positive; if negative obtain a throat culture and treat if positive; and e) treat without further tests. We defined four scenarios based on the likelihood of group A streptococcal infection using the Centor score, a well-validated clinical index. Published data were used to estimate the likelihoods of clinical outcomes and the test operating characteristics of the rapid strep test and throat culture for identifying group A streptococcal infections.

Results

Using the baseline assumptions, no testing and no treatment is preferred for patients with Centor scores of 1; two strategies--culture and treat if positive and rapid strep with culture of negative results--are equally preferable for patients with Centor scores of 2; and rapid strep with culture of negative results is the best management strategy for patients with Centor scores 3 or 4. These results are sensitive to the priorities assigned to the decision criteria, especially avoiding over-use versus under-use of antibiotics, and the population prevalence of Group A streptococcal pharyngitis.

Conclusion

The optimal clinical management of adults with sore throat depends on both the clinical probability of a group A streptococcal infection and clinical judgments that incorporate individual patient and practice circumstances.

SUBMITTER: Singh S

PROVIDER: S-EPMC1431519 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature

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Publications

Optimal management of adults with pharyngitis--a multi-criteria decision analysis.

Singh Sonal S Dolan James G JG Centor Robert M RM

BMC medical informatics and decision making 20060313

<h4>Background</h4>Current practice guidelines offer different management recommendations for adults presenting with a sore throat. The key issue is the extent to which the clinical likelihood of a Group A streptococcal infection should affect patient management decisions. To help resolve this issue, we conducted a multi-criteria decision analysis using the Analytic Hierarchy Process.<h4>Methods</h4>We defined optimal patient management using four criteria: 1) reduce symptom duration; 2) prevent ...[more]

PMID: 16533386

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Dataset Information

Optimal management of adults with pharyngitis--a multi-criteria decision analysis.

Background

Methods

Results

Conclusion

Publications

Optimal management of adults with pharyngitis--a multi-criteria decision analysis.

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