Predicting genes for orphan metabolic activities using phylogenetic profiles.
Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC1431735 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Publications
Predicting genes for orphan metabolic activities using phylogenetic profiles.
Genome biology 20060215 2
Homology-based methods fail to assign genes to many metabolic activities present in sequenced organisms. To suggest genes for these orphan activities we developed a novel method that efficiently combines local structure of a metabolic network with phylogenetic profiles. We validated our method using known metabolic genes in Saccharomyces cerevisiae and Escherichia coli. We show that our method should be easily transferable to other organisms, and that it is robust to errors in incomplete metabol ...[more]
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