Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5delta32 allele.
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ABSTRACT:
SUBMITTER: Gray L
PROVIDER: S-EPMC1440368 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
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Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5delta32 allele.
Gray Lachlan L Churchill Melissa J MJ Keane Niamh N Sterjovski Jasminka J Ellett Anne M AM Purcell Damian F J DF Poumbourios Pantelis P Kol Chenda C Wang Bin B Saksena Nitin K NK Wesselingh Steven L SL Price Patricia P French Martyn M Gabuzda Dana D Gorry Paul R PR
Journal of virology 20060401 7
We characterized human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Env) isolated from two HIV-1-infected CCR5delta32 homozygotes. Envs from both subjects used CCR5 and CXCR4 for entry into transfected cells. Most R5X4 Envs were lymphocyte-tropic and used CXCR4 exclusively for entry into peripheral blood mononuclear cells (PBMC), but a subset was dually lymphocyte- and macrophage-tropic and used either CCR5 or CXCR4 for entry into PBMC and monocyte-derived macrophages. The persi ...[more]
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