Population genetic estimation of the loss of genetic diversity during horizontal transmission of HIV-1.
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ABSTRACT:
SUBMITTER: Edwards CT
PROVIDER: S-EPMC1444934 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Publications
Population genetic estimation of the loss of genetic diversity during horizontal transmission of HIV-1.
Edwards Charles T T CT Holmes Edward C EC Wilson Daniel J DJ Viscidi Raphael P RP Abrams Elaine J EJ Phillips Rodney E RE Drummond Alexei J AJ
BMC evolutionary biology 20060323
<h4>Background</h4>Genetic diversity of the human immunodeficiency virus type 1 (HIV-1) population within an individual is lost during transmission to a new host. The demography of transmission is an important determinant of evolutionary dynamics, particularly the relative impact of natural selection and genetic drift immediately following HIV-1 infection. Despite this, the magnitude of this population bottleneck is unclear.<h4>Results</h4>We use coalescent methods to quantify the bottleneck in ...[more]
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