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CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa.

ABSTRACT: One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with Listeria monocytogenes, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa in situ and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral infection.

SUBMITTER: Laouar A

PROVIDER: S-EPMC1444945 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature

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CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa.

Laouar Amale A Haridas Viraga V Vargas Dorothy D Zhinan Xia X Chaplin David D van Lier Rene A W RA Manjunath N N

Nature immunology 20050605 7

One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with Listeria monocytogenes, proliferation and differentiation of antigen-specific T cells occurr ...[more]

PMID: 15937486

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