Ontology highlight
ABSTRACT:
SUBMITTER: van der Weyden L
PROVIDER: S-EPMC1447413 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
van der Weyden Louise L Arends Mark J MJ Chausiaux Oriane E OE Ellis Peter J PJ Lange Ulrike C UC Surani M Azim MA Affara Nabeel N Murakami Yoshinori Y Adams David J DJ Bradley Allan A
Molecular and cellular biology 20060501 9
Tumor suppressor of lung cancer 1 (TSLC1), also known as SgIGSF, IGSF4, and SynCAM, is strongly expressed in spermatogenic cells undergoing the early and late phases of spermatogenesis (spermatogonia to zygotene spermatocytes and elongating spermatids to spermiation). Using embryonic stem cell technology to generate a null mutation of Tslc1 in mice, we found that Tslc1 null male mice were infertile. Tslc1 null adult testes showed that spermatogenesis had arrested at the spermatid stage, with deg ...[more]