Ontology highlight
ABSTRACT:
SUBMITTER: Fischer JA
PROVIDER: S-EPMC1448802 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Fischer Janice A JA Acosta Shelley S Kenny Andrew A Cater Courtney C Robinson Christina C Hook Jay J
Genetics 20041101 3
The Drosophila klarsicht (klar) gene is required for developmentally regulated migrations of photoreceptor cell nuclei in the eye. klar encodes a large ( approximately 250 kD) protein with only one recognizable amino acid sequence motif, a KASH (Klar, Anc-1, Syne-1 homology) domain, at its C terminus. It has been proposed that Klar facilitates nuclear migration by linking the nucleus to the microtubule organizing center (MTOC). Here we perform genetic and immunohistochemical experiments that pro ...[more]