Ontology highlight
ABSTRACT:
SUBMITTER: Wu L
PROVIDER: S-EPMC1449641 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Wu Ligang L Fan Jihua J Belasco Joel G JG
Proceedings of the National Academy of Sciences of the United States of America 20060222 11
MicroRNAs (miRNAs) are ubiquitous regulators of eukaryotic gene expression. In addition to repressing translation, miRNAs can down-regulate the concentration of mRNAs that contain elements to which they are imperfectly complementary. Using miR-125b and let-7 as representative miRNAs, we show that in mammalian cells this reduction in message abundance is a consequence of accelerated deadenylation, which leads to rapid mRNA decay. The ability of miRNAs to expedite poly(A) removal does not result f ...[more]