Ontology highlight
ABSTRACT:
SUBMITTER: Song LS
PROVIDER: S-EPMC1449688 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Song Long-Sheng LS Sobie Eric A EA McCulle Stacey S Lederer W J WJ Balke C William CW Cheng Heping H
Proceedings of the National Academy of Sciences of the United States of America 20060306 11
Heart muscle is characterized by a regular array of proteins and structures that form a repeating functional unit identified as the sarcomere. This regular structure enables tight coupling between electrical activity and Ca(2+) signaling. In heart failure, multiple cellular defects develop, including reduced contractility, altered Ca(2+) signaling, and arrhythmias; however, the underlying causes of these defects are not well understood. Here, in ventricular myocytes from spontaneously hypertensi ...[more]