The Ku protein complex is involved in length regulation of Drosophila telomeres.
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ABSTRACT:
SUBMITTER: Melnikova L
PROVIDER: S-EPMC1449706 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Publications
The Ku protein complex is involved in length regulation of Drosophila telomeres.
Melnikova Larisa L Biessmann Harald H Georgiev Pavel P
Genetics 20050321 1
Chromosome ends in Drosophila melanogaster can be elongated either by terminal attachment of the telomere-specific retrotransposons HeT-A and TART or by terminal gene conversion. Here we show that a decrease in Ku70 or Ku80 gene dosage causes a sharp increase in the frequency of HeT-A and TART attachments to a broken chromosome end and in terminal DNA elongation by gene conversion. Loss of Ku80 has more pronounced effects than loss of Ku70. However, lower Ku70 concentration reduces the stability ...[more]
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