Ontology highlight
ABSTRACT:
SUBMITTER: Smits BM
PROVIDER: S-EPMC1449770 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Smits Bart M G BM Peters Theo A TA Mul Joram D JD Croes Huib J HJ Fransen Jack A M JA Beynon Andy J AJ Guryev Victor V Plasterk Ronald H A RH Cuppen Edwin E
Genetics 20050618 4
The rat is the most extensively studied model organism and is broadly used in biomedical research. Current rat disease models are selected from existing strains and their number is thereby limited by the degree of naturally occurring variation or spontaneous mutations. We have used ENU mutagenesis to increase genetic variation in laboratory rats and identified a recessive mutant, named tornado, showing aberrant circling behavior, hyperactivity, and stereotypic head shaking. More detailed analysi ...[more]