Ontology highlight
ABSTRACT:
SUBMITTER: Giorgini F
PROVIDER: S-EPMC1449881 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Giorgini Flaviano F Guidetti Paolo P Nguyen QuangVu Q Bennett Simone C SC Muchowski Paul J PJ
Nature genetics 20050403 5
Huntington disease is a fatal neurodegenerative disorder caused by expansion of a polyglutamine tract in the protein huntingtin (Htt), which leads to its aggregation in nuclear and cytoplasmic inclusion bodies. We recently identified 52 loss-of-function mutations in yeast genes that enhance the toxicity of a mutant Htt fragment. Here we report the results from a genome-wide loss-of-function suppressor screen in which we identified 28 gene deletions that suppress toxicity of a mutant Htt fragment ...[more]