Ontology highlight
ABSTRACT:
SUBMITTER: Kotti TJ
PROVIDER: S-EPMC1450160 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Kotti Tiina J TJ Ramirez Denise M O DM Pfeiffer Brad E BE Huber Kimberly M KM Russell David W DW
Proceedings of the National Academy of Sciences of the United States of America 20060227 10
The mevalonate pathway produces cholesterol and nonsterol isoprenoids, such as geranylgeraniol. In the brain, a fraction of cholesterol is metabolized in neurons by the enzyme cholesterol 24-hydroxylase, and this depletion activates the mevalonate pathway. Brains from mice lacking 24-hydroxylase excrete cholesterol more slowly, and the tissue compensates by suppressing the mevalonate pathway. Here we report that this suppression causes a defect in learning. 24-Hydroxylase knockout mice exhibit s ...[more]