The C-terminal domain of pol II and a DRB-sensitive kinase are required for 3' processing of U2 snRNA.
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ABSTRACT:
SUBMITTER: Medlin JE
PROVIDER: S-EPMC145437 | biostudies-literature | 2003 Feb
REPOSITORIES: biostudies-literature
Publications
The C-terminal domain of pol II and a DRB-sensitive kinase are required for 3' processing of U2 snRNA.
Medlin Joanne E JE Uguen Patricia P Taylor Alice A Bentley David L DL Murphy Shona S
The EMBO journal 20030201 4
The human snRNA genes transcribed by RNA polymerase II (e.g. U1 and U2) have a characteristic TATA-less promoter containing an essential proximal sequence element. Formation of the 3' end of these non-polyadenylated RNAs requires a specialized 3' box element whose function is promoter specific. Here we show that truncation of the C-terminal domain (CTD) of RNA polymerase II and treatment of cells with CTD kinase inhibitors, including DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole), causes ...[more]
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