Ontology highlight
ABSTRACT:
SUBMITTER: Mokranjac D
PROVIDER: S-EPMC145450 | biostudies-literature | 2003 Feb
REPOSITORIES: biostudies-literature
Mokranjac Dejana D Paschen Stefan A SA Kozany Christian C Prokisch Holger H Hoppins Suzanne C SC Nargang Frank E FE Neupert Walter W Hell Kai K
The EMBO journal 20030201 4
The preprotein translocase of the inner membrane of mitochondria (TIM23 complex) is the main entry gate for proteins of the matrix and the inner membrane. We isolated the TIM23 complex of Neurospora crassa. Besides Tim23 and Tim17, it contained a novel component, referred to as Tim50. Tim50 spans the inner membrane with a single transmembrane segment and exposes a large hydrophilic domain in the intermembrane space. Tim50 is essential for viability of yeast. Mitochondria from cells depleted of T ...[more]