Ontology highlight
ABSTRACT:
SUBMITTER: Bader MW
PROVIDER: S-EPMC145499 | biostudies-literature | 2001 Apr
REPOSITORIES: biostudies-literature
The EMBO journal 20010401 7
There are two distinct pathways for disulfide formation in prokaryotes. The DsbA-DsbB pathway introduces disulfide bonds de novo, while the DsbC-DsbD pathway functions to isomerize disulfides. One of the key questions in disulfide biology is how the isomerase pathway is kept separate from the oxidase pathway in vivo. Cross-talk between these two systems would be mutually destructive. To force communication between these two systems we have selected dsbC mutants that complement a dsbA null mutati ...[more]