Ontology highlight
ABSTRACT:
SUBMITTER: Johnson DJ
PROVIDER: S-EPMC1456925 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Johnson Daniel J D DJ Li Wei W Adams Ty E TE Huntington James A JA
The EMBO journal 20060413 9
Regulation of blood coagulation is critical for maintaining blood flow, while preventing excessive bleeding or thrombosis. One of the principal regulatory mechanisms involves heparin activation of the serpin antithrombin (AT). Inhibition of several coagulation proteases is accelerated by up to 10,000-fold by heparin, either through bridging AT and the protease or by inducing allosteric changes in the properties of AT. The anticoagulant effect of short heparin chains, including the minimal AT-spe ...[more]