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Genome-wide analysis of developmental and sex-regulated gene expression profiles in Caenorhabditis elegans.


ABSTRACT: We have constructed DNA microarrays containing 17,871 genes, representing about 94% of the 18,967 genes currently annotated in the Caenorhabditis elegans genome. These DNA microarrays can be used as a tool to define a nearly complete molecular profile of gene expression levels associated with different developmental stages, growth conditions, or worm strains. Here, we used these full-genome DNA microarrays to show the relative levels of gene expression for nearly every gene during development, from eggs through adulthood. These expression data can help reveal when a gene may act during development. We also compared gene expression in males to that of hermaphrodites and found a total of 2,171 sex-regulated genes (P < 0.05). The sex-regulated genes provide a global view of the differences between the sexes at a molecular level and identify many genes likely to be involved in sex-specific differentiation and behavior.

SUBMITTER: Jiang M 

PROVIDER: S-EPMC14571 | biostudies-literature | 2001 Jan

REPOSITORIES: biostudies-literature

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Genome-wide analysis of developmental and sex-regulated gene expression profiles in Caenorhabditis elegans.

Jiang M M   Ryu J J   Kiraly M M   Duke K K   Reinke V V   Kim S K SK  

Proceedings of the National Academy of Sciences of the United States of America 20010101 1


We have constructed DNA microarrays containing 17,871 genes, representing about 94% of the 18,967 genes currently annotated in the Caenorhabditis elegans genome. These DNA microarrays can be used as a tool to define a nearly complete molecular profile of gene expression levels associated with different developmental stages, growth conditions, or worm strains. Here, we used these full-genome DNA microarrays to show the relative levels of gene expression for nearly every gene during development, f  ...[more]

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