Ontology highlight
ABSTRACT:
SUBMITTER: Ennifar E
PROVIDER: S-EPMC1458285 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Ennifar Eric E Paillart Jean-Christophe JC Bodlenner Anne A Walter Philippe P Weibel Jean-Marc JM Aubertin Anne-Marie AM Pale Patrick P Dumas Philippe P Marquet Roland R
Nucleic acids research 20060505 8
The kissing-loop complex that initiates dimerization of genomic RNA is crucial for Human Immunodeficiency Virus Type 1 (HIV-1) replication. We showed that owing to its strong similitude with the bacterial ribosomal A site it can be targeted by aminoglycosides. Here, we present its crystal structure in complex with neamine, ribostamycin, neomycin and lividomycin. These structures explain the specificity for 4,5-disubstituted 2-deoxystreptamine (DOS) derivatives and for subtype A and subtype F kis ...[more]