Ontology highlight
ABSTRACT:
SUBMITTER: Schwartz TU
PROVIDER: S-EPMC1458978 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20060420 18
Protein translocation across and insertion into membranes is essential to all life forms. Signal peptide-bearing nascent polypeptide chains emerging from the ribosome are first sampled by the signal-recognition particle (SRP), then targeted to the membrane via the SRP receptor (SR), and, finally, transferred to the protein-conducting channel. In eukaryotes, this process is tightly controlled by the concerted action of three G proteins, the 54-kD subunit of SRP and the alpha- and beta-subunits of ...[more]