Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC1459354 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Liu Sijiu S Sun Jin-Peng JP Zhou Bo B Zhang Zhong-Yin ZY
Proceedings of the National Academy of Sciences of the United States of America 20060327 14
Mitogen-activated protein (MAP) kinases are central components of signal transduction pathways for cell proliferation, stress responses, and differentiation. Signaling efficiency and specificity are modulated in large part by docking interactions between individual MAP kinase and the kinase interaction motif (KIM), (R/K)(2-3)-X(1-6)-Phi(A)-X-Phi(B), in its cognate kinases, phosphatases, scaffolding proteins, and substrates. We have determined the crystal structure of extracellular signal-regulat ...[more]