Neuronal metabolism governs cortical network response state.
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ABSTRACT:
SUBMITTER: Cunningham MO
PROVIDER: S-EPMC1459399 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Publications
Neuronal metabolism governs cortical network response state.
Cunningham M O MO Pervouchine D D DD Racca C C Kopell N J NJ Davies C H CH Jones R S G RS Traub R D RD Whittington M A MA
Proceedings of the National Academy of Sciences of the United States of America 20060324 14
The level of arousal in mammals is correlated with metabolic state and specific patterns of cortical neuronal responsivity. In particular, rhythmic transitions between periods of high activity (up phases) and low activity (down phases) vary between wakefulness and deep sleep/anesthesia. Current opinion about changes in cortical response state between sleep and wakefulness is split between neuronal network-mediated mechanisms and neuronal metabolism-related mechanisms. Here, we demonstrate that s ...[more]
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