Ontology highlight
ABSTRACT:
SUBMITTER: Takayasu S
PROVIDER: S-EPMC1464357 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Takayasu Shinobu S Sakurai Takeshi T Iwasaki Satoshi S Teranishi Hitoshi H Yamanaka Akihiro A Williams S Clay SC Iguchi Haruhisa H Kawasawa Yuka Imamura YI Ikeda Yukio Y Sakakibara Iori I Ohno Kousaku K Ioka Ryoichi X RX Murakami Saori S Dohmae Naoshi N Xie Jian J Suda Toshihiro T Motoike Toshiyuki T Ohuchi Takashi T Yanagisawa Masashi M Sakai Juro J
Proceedings of the National Academy of Sciences of the United States of America 20060428 19
Here, we report the isolation and characterization of an endogenous peptide ligand of GPR103 from rat brains. The purified peptide was found to be the 43-residue RF-amide peptide QRFP. We also describe two mouse homologues of human GPR103, termed mouse GPR103A and GPR103B. QRFP binds and activates the human GPR103, as well as mouse GPR103A and GPR103B, with nanomolar affinities in transfected cells. Systematic in situ hybridization analysis in mouse brains showed that QRFP is expressed exclusive ...[more]