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The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome.

ABSTRACT: BACKGROUND: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-gamma,TNF-alpha and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). METHODS: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-gamma,TNF-alpha and IL-10 for their associations with SARS. RESULTS: IFN-gamma +874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-gamma +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-alpha were not associated with SARS susceptibility. CONCLUSION: IFN-gamma +874A allele was shown to be a risk factor in SARS susceptibility.

SUBMITTER: Chong WP 

PROVIDER: S-EPMC1468415 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature

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The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome.

Chong Wai Po WP   Ip W K Eddie WK   Tso Gloria Hoi Wan GH   Ng Man Wai MW   Wong Wilfred Hing Sang WH   Law Helen Ka Wai HK   Yung Raymond W H RW   Chow Eudora Y EY   Au K L KL   Chan Eric Y T EY   Lim Wilina W   Peiris J S Malik JS   Lau Yu Lung YL  

BMC infectious diseases 20060504

<h4>Background</h4>Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-gamma,TNF-alpha and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).<h4>Methods</h4>A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-gamma,TNF-alpha and IL-10 for their associations with SARS.<h4>Results</h4>IFN-gamma +874A allele was associated with susceptibility t  ...[more]

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