Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC14694 | biostudies-literature | 2001 Jan
REPOSITORIES: biostudies-literature
Zhang Y Y Chang C C Gehling D J DJ Hemmati-Brivanlou A A Derynck R R
Proceedings of the National Academy of Sciences of the United States of America 20010101 3
Smad proteins are key intracellular signaling effectors for the transforming growth factor-beta superfamily of peptide growth factors. Following receptor-induced activation, Smads move into the nucleus to activate transcription of a select set of target genes. The activity of Smad proteins must be tightly regulated to exert the biological effects of different ligands in a timely manner. Here, we report the identification of Smurf2, a new member of the Hect family of E3 ubiquitin ligases. Smurf2 ...[more]