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Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8.

ABSTRACT: Mammalian oogenesis requires oocyte-specific transcriptional regulators. The full complement of oocyte-specific transcription factors is unknown. Here, we describe the finding that Sohlh1, a spermatogenesis and oogenesis basic helix-loop-helix transcription factor in females, is preferentially expressed in oocytes and required for oogenesis. Sohlh1 disruption perturbs follicular formation in part by causing down-regulation of two genes that are known to disrupt folliculogenesis: newborn ovary homeobox gene (Nobox) and factor in the germ-line alpha (Figla). In addition, we show that Lhx8 is downstream of Sohlh1 and critical in fertility. Thus, Sohlh1 and Lhx8 are two germ cell-specific, critical regulators of oogenesis.

SUBMITTER: Pangas SA

PROVIDER: S-EPMC1472434 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature

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Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8.

Pangas Stephanie A SA Choi Youngsok Y Ballow Daniel J DJ Zhao Yangu Y Westphal Heiner H Matzuk Martin M MM Rajkovic Aleksandar A

Proceedings of the National Academy of Sciences of the United States of America 20060511 21

Mammalian oogenesis requires oocyte-specific transcriptional regulators. The full complement of oocyte-specific transcription factors is unknown. Here, we describe the finding that Sohlh1, a spermatogenesis and oogenesis basic helix-loop-helix transcription factor in females, is preferentially expressed in oocytes and required for oogenesis. Sohlh1 disruption perturbs follicular formation in part by causing down-regulation of two genes that are known to disrupt folliculogenesis: newborn ovary ho ...[more]

PMID: 16690745

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