Ontology highlight
ABSTRACT:
SUBMITTER: Woods CG
PROVIDER: S-EPMC1474039 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Woods C Geoffrey CG Cox James J Springell Kelly K Hampshire Daniel J DJ Mohamed Moin D MD McKibbin Martin M Stern Rowena R Raymond F Lucy FL Sandford Richard R Malik Sharif Saghira S Karbani Gulshan G Ahmed Mustaq M Bond Jacquelyn J Clayton David D Inglehearn Chris F CF
American journal of human genetics 20060321 5
Individuals born of consanguineous union have segments of their genomes that are homozygous as a result of inheriting identical ancestral genomic segments through both parents. One consequence of this is an increased incidence of recessive disease within these sibships. Theoretical calculations predict that 6% (1/16) of the genome of a child of first cousins will be homozygous and that the average homozygous segment will be 20 cM in size. We assessed whether these predictions held true in popula ...[more]