Ontology highlight
ABSTRACT:
SUBMITTER: Castella S
PROVIDER: S-EPMC1474052 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Castella Sandrine S Bingham Gregg G Sanders Cyril M CM
Nucleic acids research 20060531 10
E1 and T-antigen of the tumour viruses bovine papillomavirus (BPV-1) and Simian virus 40 (SV40) are the initiator proteins that recognize and melt their respective origins of replication in the initial phase of DNA replication. These proteins then assemble into processive hexameric helicases upon the single-stranded DNA that they create. In T-antigen, a characteristic loop and hairpin structure (the pre-sensor 1beta hairpin, PS1betaH) project into a central cavity generated by protein hexameriza ...[more]