Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis.
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ABSTRACT:
SUBMITTER: Ekelund E
PROVIDER: S-EPMC1474106 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Publications
Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis.
Ekelund E E Saaf A A Tengvall-Linder M M Melen E E Link J J Barker J J Reynolds N J NJ Meggitt S J SJ Kere J J Wahlgren C-F CF Pershagen G G Wickman M M Nordenskjold M M Kockum I I Bradley M M
American journal of human genetics 20060414 6
In a systematic analysis of global gene-expression patterns, we found that SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls, and immunohistochemical analysis confirmed a similar elevation of SOCS3 protein. Furthermore, we found a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene in two independent groups of patients (P<.02 and P<.03). These results strongly suggest that SOCS3, ...[more]
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2016-11-13 | GSE72449 | GEO