Ontology highlight
ABSTRACT:
SUBMITTER: Sen SK
PROVIDER: S-EPMC1474114 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Sen Shurjo K SK Han Kyudong K Wang Jianxin J Lee Jungnam J Wang Hui H Callinan Pauline A PA Dyer Matthew M Cordaux Richard R Liang Ping P Batzer Mark A MA
American journal of human genetics 20060503 1
Recombination between Alu elements results in genomic deletions associated with many human genetic disorders. Here, we compare the reference human and chimpanzee genomes to determine the magnitude of this recombination process in the human lineage since the human-chimpanzee divergence approximately 6 million years ago. Combining computational data mining and wet-bench experimental verification, we identified 492 human-specific deletions (for a total of approximately 400 kb) attributable to this ...[more]