Ontology highlight
ABSTRACT:
SUBMITTER: Oates NA
PROVIDER: S-EPMC1474116 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Oates N A NA van Vliet J J Duffy D L DL Kroes H Y HY Martin N G NG Boomsma D I DI Campbell M M Coulthard M G MG Whitelaw E E Chong S S
American journal of human genetics 20060522 1
The AXIN1 gene has been implicated in caudal duplication anomalies. Its coding region was sequenced in both members of a monozygotic (MZ) twin pair discordant for a caudal duplication anomaly, but no mutation was found. Using bisulfite sequencing, we examined methylation at the promoter region of the AXIN1 gene in these twins and in twin and age-matched singleton controls. Methylation of the promoter region in peripheral blood mononucleated cells was variable among individuals, including MZ pair ...[more]