Ontology highlight
ABSTRACT:
SUBMITTER: Ning K
PROVIDER: S-EPMC1478173 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Ning Ke K Miller Lisa C LC Laidlaw Hilary A HA Burgess Laura A LA Perera Nevin M NM Downes C Peter CP Leslie Nick R NR Ashford Michael L J ML
The EMBO journal 20060504 11
In obesity and diabetes, the ability of hypothalamic neurons to sense and transduce changes in leptin and insulin levels is compromised. The effects of both hormones require intracellular signalling via the PI3-kinase pathway, which is inhibited by the phosphatase PTEN. We show that leptin-stimulated F-actin depolymerization in mouse hypothalamic cells is inhibited by PTEN, a process involving independent effects of both its lipid and protein phosphatase activities. Potentially mediating this F- ...[more]