Ontology highlight
ABSTRACT:
SUBMITTER: Bomgarden RD
PROVIDER: S-EPMC1478198 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Bomgarden Ryan D RD Lupardus Patrick J PJ Soni Deena V DV Yee Muh-Ching MC Ford James M JM Cimprich Karlene A KA
The EMBO journal 20060504 11
An essential component of the ATR (ataxia telangiectasia-mutated and Rad3-related)-activating structure is single-stranded DNA. It has been suggested that nucleotide excision repair (NER) can lead to activation of ATR by generating such a signal, and in yeast, DNA damage processing through the NER pathway is necessary for checkpoint activation during G1. We show here that ultraviolet (UV) radiation-induced ATR signaling is compromised in XPA-deficient human cells during S phase, as shown by defe ...[more]