Ontology highlight
ABSTRACT:
SUBMITTER: Magarvey NA
PROVIDER: S-EPMC1479125 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Magarvey Nathan A NA Haltli Brad B He Min M Greenstein Michael M Hucul John A JA
Antimicrobial agents and chemotherapy 20060601 6
The mannopeptimycins are a novel class of lipoglycopeptide antibiotics active against multidrug-resistant pathogens with potential as clinically useful antibacterials. This report is the first to describe the biosynthesis of this novel class of mannosylated lipoglycopeptides. Included here are the cloning, sequencing, annotation, and manipulation of the mannopeptimycin biosynthetic gene cluster from Streptomyces hygroscopicus NRRL 30439. Encoded by genes within the mannopeptimycin biosynthetic g ...[more]