Impact of human immunodeficiency virus type 1 subtype C on drug resistance mutations in patients from Botswana failing a nelfinavir-containing regimen.
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ABSTRACT:
SUBMITTER: Doualla-Bell F
PROVIDER: S-EPMC1479146 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
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Impact of human immunodeficiency virus type 1 subtype C on drug resistance mutations in patients from Botswana failing a nelfinavir-containing regimen.
Doualla-Bell Florence F Avalos Ava A Gaolathe Tendani T Mine Madisa M Gaseitsiwe Simani S Ndwapi Ndwapi N Novitsky Vladimir A VA Brenner Bluma B Oliveira Maureen M Moisi Daniella D Moffat Howard H Thior Ibou I Essex Max M Wainberg Mark A MA
Antimicrobial agents and chemotherapy 20060601 6
Among 16 human immunodeficiency virus-infected (subtype C) Batswana patients who failed nelfinavir (NFV)-containing regimens, the most prevalent mutation observed was D30N (54%), followed by L90M (31%). L89I, K20T/I, and E35D polymorphic changes were also identified. These findings suggest that subtype C viruses in Botswana may develop resistance to NFV via subtype-specific pathways. ...[more]
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