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Impact of human immunodeficiency virus type 1 subtype C on drug resistance mutations in patients from Botswana failing a nelfinavir-containing regimen.

ABSTRACT: Among 16 human immunodeficiency virus-infected (subtype C) Batswana patients who failed nelfinavir (NFV)-containing regimens, the most prevalent mutation observed was D30N (54%), followed by L90M (31%). L89I, K20T/I, and E35D polymorphic changes were also identified. These findings suggest that subtype C viruses in Botswana may develop resistance to NFV via subtype-specific pathways.

SUBMITTER: Doualla-Bell F 

PROVIDER: S-EPMC1479146 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature

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Impact of human immunodeficiency virus type 1 subtype C on drug resistance mutations in patients from Botswana failing a nelfinavir-containing regimen.

Doualla-Bell Florence F   Avalos Ava A   Gaolathe Tendani T   Mine Madisa M   Gaseitsiwe Simani S   Ndwapi Ndwapi N   Novitsky Vladimir A VA   Brenner Bluma B   Oliveira Maureen M   Moisi Daniella D   Moffat Howard H   Thior Ibou I   Essex Max M   Wainberg Mark A MA  

Antimicrobial agents and chemotherapy 20060601 6

Among 16 human immunodeficiency virus-infected (subtype C) Batswana patients who failed nelfinavir (NFV)-containing regimens, the most prevalent mutation observed was D30N (54%), followed by L90M (31%). L89I, K20T/I, and E35D polymorphic changes were also identified. These findings suggest that subtype C viruses in Botswana may develop resistance to NFV via subtype-specific pathways. ...[more]

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