Constitutive differences in gene expression profiles parallel genetic patterns of susceptibility to tuberculosis in mice.
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ABSTRACT:
SUBMITTER: Orlova MO
PROVIDER: S-EPMC1479297 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Publications
Constitutive differences in gene expression profiles parallel genetic patterns of susceptibility to tuberculosis in mice.
Orlova Marianna O MO Majorov Konstantin B KB Lyadova Irina V IV Eruslanov Eugenii B EB M'lan Cyr E CE Greenwood Celia M T CM Schurr Erwin E Apt Alexander S AS
Infection and immunity 20060601 6
Interstitial lung macrophages from tuberculosis-susceptible I/St and tuberculosis-resistant A/Sn mice demonstrated significant constitutive differences in gene expression levels, whereas in vitro infection of these cells with Mycobacterium tuberculosis had only a modulatory impact on gene expression. We conclude that intrinsic gene expression profiles are an important determinant of tuberculosis pathogenesis in mice. ...[more]
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