Ontology highlight
ABSTRACT:
SUBMITTER: Brinkman AB
PROVIDER: S-EPMC1479594 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Brinkman Arie B AB Roelofsen Thijs T Pennings Sebastiaan W C SW Martens Joost H A JH Jenuwein Thomas T Stunnenberg Hendrik G HG
EMBO reports 20060428 6
X inactivation is associated with chromosome-wide establishment of inactive chromatin. Although this is classically regarded as facultative heterochromatin that is uniform in nature, the exact distribution of associated epigenetic marks is not well defined. Here we have analysed histone modifications in human somatic cells within two selected regions of the X chromosome. Intergenic, coding and promoter regions are segregated into differentially marked chromatin. H3K27me3 is most prominent in int ...[more]