Ontology highlight
ABSTRACT:
SUBMITTER: Habashi JP
PROVIDER: S-EPMC1482474 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20060401 5770
Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that encodes fibrillin-1. Selected manifestations of MFS reflect excessive signaling by the transforming growth factor-beta (TGF-beta) family of cytokines. We show that aortic aneurysm in a mouse model of MFS is associated with increased TGF-beta signaling and can be prevented by TGF-beta antagonists such as TGF-beta-neutralizing antibody or the angiotensin II type 1 receptor (A ...[more]